I'm not going max effort on it. 350 hp or so will make me happy for now.
350hp will be a cake walk. I have a later factory balance shaft block bottom with Vortec and custom cam. My truck is making 450+hp at 14psi. Even if I had stock cam and Vortec heads, I don't think it would be that difficult to make 500hp+ with higher boost levels and the 2114 intake has better air flow distribution (and I suspect air flow) than the factory SyTy intake manifold. The biggest question is if the factory short block will take it.